Regular ArticleComplete Coding Sequence, Deduced Primary Structure, Chromosomal Localization, and Structural Analysis of Murine Aggrecan
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Structure, function, aging and turnover of aggrecan in the intervertebral disc
2014, Biochimica et Biophysica Acta - General SubjectsMultiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage
2012, Matrix BiologyCitation Excerpt :Thus enhancers lying within the first intron in human are seemingly located upstream of the gene in many other species. Conversely, an additional upstream non‐coding exon has been annotated for the mouse gene (Walcz et al., 1994), making the homologues of the − 11ACAN and − 34ACAN enhancers fall within the first intron. Interestingly, the + 30ACAN enhancer overlaps with an expressed sequence tag (EST) from a chondrosarcoma line, and the orthologous chicken sequence overlaps with two ESTs isolated from cartilage, suggesting that this conserved enhancer sequence is normally transcribed in cartilage.
Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice
2007, Journal of Biological ChemistryCitation Excerpt :The radiolabeled aggrecan peptides 1, 2a, and 2b present in the matrix and peptides 1–7 present in the medium of wild-type cartilage cultures are shown in Fig. 2A and represented schematically in Fig. 3A. The fragment numbers are the same as those published previously for stimulated and unstimulated cartilage cultures (3, 23, 43). Compared with unstimulated cultures, a more extensive degradation of radiolabeled aggrecan was observed in cultures treated with IL-1α; the cartilage extracts contained reduced levels of intact aggrecan (Fig. 2A, a and b).
Link protein can retard the degradation of hyaluronan in proteoglycan aggregates
2006, Osteoarthritis and CartilageThe glycosaminoglycan attachment regions of human aggrecan
2006, Journal of Biological ChemistryADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures
2006, Osteoarthritis and Cartilage