Elsevier

Genomics

Volume 15, Issue 1, January 1993, Pages 200-202
Genomics

Short Communication
The Pituitary Hormones Arginine Vasopressin-Neurophysin II and Oxytocin-Neurophysin I Show Close Linkage with Interleukin-1 on Mouse Chromosome 2

https://doi.org/10.1006/geno.1993.1034Get rights and content

Abstract

Arginine vasopressin (AVP) and oxytocin (OXT) are posterior pituitary hormones. AVP is involved in fluid homeostasis, while OXT is involved in lactation and parturition. AVP is derived from a larger precursor, prepro-arginine-vasopressin-neurophysin II (prepro-AVP-NP II; AVP ), and is physically linked to prepro-oxytocin-neurophysin I (prepro-OXT-NP I; OXT). The genes for AVP and OXT are separated by only 12 kb of DNA in humans, whereas in time mouse 3.5 kb of intergenic sequence lies between Avp and Oxt. Interspecific backcross analysis has now been used to map the Avp/Oxt complex to chromosome 2 in the mouse. This map position confirms and extends the known region of linkage conservation between mouse chromosome 2 and human chromosome 20.

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