Studies on the enzymatic degradation of the cholesterol side chain. II. Requirements of the mitochondrial system

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Abstract

Further observations on the oxidation of the terminal carbon of cholesterol-26-C14 by mouse liver mitochondria have been presented. The present system permits recovery of up to 15% of the isotopic carbon as C14O2 after 4 hr. incubation. Partial purification of the heat-stable soluble cofactor required for C14O2 production has been achieved.

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