Initiation of lipid peroxidation by a reduced metal ion

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Abstract

Ferrous iron was more effective than ferric in the initiation of peroxidation of heterogeneous linoleatc at 30 °C. The oxidation observed for ferric catalysis was autocatalytic in nature. Ferrous iron caused a linear uptake of oxygen, except in the more dilute solutions in which the reaction was first linear and subsequently autocatalytic. The results are considered in relation to a hypothesis that the reduced ion is involved in initiation of lipid peroxidation. It is proposed that a perhydroxyl radical is produced by the reduced metal ion. The hypothesis is discussed in relation to other systems.

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    Present address: Hawkesbury Agricultural College, Richmond, N.S.W., Australia.

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