Alkylation of DNA and proteins in mice exposed to vinyl chloride
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Literature review and evaluation of biomarkers, matrices and analytical methods for chemicals selected in the research program Human Biomonitoring for the European Union (HBM4EU)
2022, Environment InternationalCitation Excerpt :This includes the formation of adducts of xenobiotics with biomolecules, such as the hemoglobin (Hb)-, albumin-, and DNA-adducts (Henderson et al. 1989). A quantitative relationship between DNA-adducts and hemoglobin adducts in mice was reported for ethylene oxide (Ehrenberg et al. 1974) or vinyl chloride (Osterman-Golkar et al. 1976). 2-Acetylaminofluorene (Pereira et al. 1981) reacted with Hb and DNA of the target organ in a dose-dependent manner.
Direct quantitation of hydroxyethylvaline in hemoglobin by liquid chromatography/positive electrospray tandem mass spectrometry
2012, Journal of Chromatography ACitation Excerpt :Therefore, reliable, simple, and accurate methods for quantifying HEVal are key to provision of internal dose information for such studies. Very early methods to quantify these alkylated hemoglobin adducts (such as hydroxyethylated hemoglobin adducts) from animal exposures involved the use of radioactively labeled alkylating agents, which, upon adduct isolation and subsequent radioactivity counting, were quantified by virtue of the radioactive label [6–8]. This traditional procedure is expensive because it requires the synthesis of radiolabeled reactive chemicals (or active chemical metabolites) and it necessitates special precautions for proper radiochemical handling of samples.
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1997, Journal of Chromatography B: Biomedical ApplicationsVinyl chloride mechanistic data and risk assessment: DNA reactivity and cross-species quantitative risk extrapolation
1996, Pharmacology and TherapeuticsGenetic toxicology of vinyl chloride-a review
1995, Mutation Research/Reviews in Genetic Toxicology