Specificity of salivary-bacterial interactions: II. Evidence for a lectin on with specificity for a NeuAcα2,3Ga1β1,3Ga1NAc sequence
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Glycan recognition at the saliva – oral microbiome interface
2018, Cellular ImmunologyCitation Excerpt :Oral streptococci express multiple adhesins [124] which allow them to recognize a wide spectrum of adhesion substrates, including salivary glycoproteins present in the acquired enamel pellicle on the tooth surface. [125,126]. The existence of a streptococcal lectin that binds host sialic acids on salivary mucins, was first discovered in the late 1970′s [28,29,127]. Later, a lectin-like adhesin expressed by S. gordonii DL1, named Hsa, was isolated based on its ability to bind sialic acid on red blood cells, and was found to be a high molecular weight glycoprotein associated with fibrillar structures on the bacterial surface [128].
Nanostructuring Biomaterials with Specific Activities towards Digestive Enzymes for Controlled Gastrointestinal Absorption of Lipophilic Bioactive Molecules
2016, Advances in Colloid and Interface ScienceCitation Excerpt :A complex series of physicochemical, physiological and biochemical events are initiated in the mouth and throat [54–56]. In the oral cavity, lipid interacts with saliva which is a neutral, viscoelastic fluid that contains low mineral content and a mixture of proteins, known as glycoprotein mucin [57]. The protein content of saliva can drastically alter the lipid structural and droplet dispersion through coalescence, electrostatic interactions or depletion mechanisms [58–60].
The role of mucin-type O-glycans in eukaryotic development
2010, Seminars in Cell and Developmental BiologyScience is the fuel for the engine of technology and clinical practice
2009, Journal of the American Dental AssociationCitation Excerpt :While working at the University at Buffalo, The State University of New York, Michael Levine spawned several important discoveries regarding salivary proteins.79 Levine and his colleagues identified the importance of salivary proteins as part of the framework for bacterial adherence to the teeth via bacterial proteins that interact with specific domains within salivary proteins, forming a molecular fastener similar to Velcro.80 Other dental scientists who began their careers at the University at Buffalo contributed to our understanding of streptococci in the aggregation of human platelets and virulence factors associated with bacterial endocarditis.81,82
Lactones of disialyl lactose: Characterisation by NMR and mass spectra
2006, Carbohydrate ResearchCitation Excerpt :Mammalian milk sugars contain a highly complex mixture of sialyl oligosaccharides. They are of considerable interest because of their varied biological functions, such as cell surface receptors for pathogens.9,10 In sialyl oligosaccharides, lactonisation can occur between the carboxyl group of Neu5Ac and a hydroxyl group of an adjacent sugar residue.
Oligosaccharides
2003, Functional Dairy Products: Volume 1