Biochemical and Biophysical Research Communications
Volume 134, Issue 1, 14 January 1986, Pages 100-106
Regioselective glutathione conjugation of the carcinogen, 7,12-dihydroxymethylbenz[α]anthracene, via reactive 7-hydroxymethyl sulfate ester in rat liver cytosol
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Metabolite identification and profile of endosulfan sulfate in three human liver preparations using liquid chromatography-high resolution mass spectrometry
2020, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :In particular, ions at m/z 74.02268, m/z 128.03369, m/z 143.04459, and m/z 272.08857 were characteristic product ions for the MS fragmentation of GSH [12], and thus M3 was interpreted to be an endosulfan sulfate-GSH conjugate. Because the isotope pattern of molecular ion of M3 was conserved, this conjugation reaction was not suggested to be a halogen (chlorine) substitution reaction [13], but instead was a conjugation of GSH and the methylene carbon with a loss of the sulfate anion from the sulfate ester form mediated by GSH s-transferase [14]. M4 was detected only in human liver microsomes and showed an [M−H]− ion at m/z 714.88287, which is approximately 16 amu greater than M3.
Benzylic carbonium ions as ultimate carcinogens of polynuclear aromatic hydrocarbons
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1994, Chemico-Biological InteractionsAlteration of precocene II-induced hepatotoxicity by modulation of hepatic glutathione levels
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