Specific estrogen-receptors in the neoplastic and lactating mammary gland of the rat

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Abstract

Specific receptors of 3H-estradiol-17β were demonstrated by a sucrose gradient assay of cytosols from the lactating mammary gland and the R3230AC mammary adenocarcinoma of the rat. These estrogen receptors, each of which sedimented at approximately 8S, exhibited similar dissociation constants (Kd∼1×10−9M) and steroid binding specificities. Ovariectomy of the host had no apparent effect on the number of binding sites/mg protein in the R3230AC tumor.

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    Supported in part by the Irwin Strasburger Memorial Medical Foundation and USPHS Grants CA-11198 and CA-12836.

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    Medical Student Fellow supported by USPHS-General Research Support Grant.

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    American Cancer Society Summer Fellow.

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