Induction of sister chromatid exchanges by nicotinamide in Chinese hamster lung fibroblasts and human lymphoblastoid cells

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Summary

Nicotinamide, which occurs naturally, produced sister chromatid exchanges in Chinese hamster lung fibroblasts and human lymphoblastoid cells. The inductions were dose-dependent with concentrations of 1.0–10.0 mM nicotinamide. Elastatinal, a protease inhibitor that has been reported to suppress induction of sister chromatid exchanges by N-methyl-N′-nitro-N-nitrosoguanidine, did not suppress induction of sister chromatid exchanges by nicotinamide in these cell lines.

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    This work was partially supported by Grants-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, and the Ministry of Health and Welfare of Japan.

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