Journal of Ultrastructure Research
Topography of lymphocyte surface immunoglobulin using scanning immunoelectron microscopy
References (30)
- et al.
FEBS Letters
(1973) - et al.
Biochim. Biophys. Acta
(1973) - et al.
Cell Immunol.
(1974) Cell. Immunol.
(1974)- et al.
J. Immunol.
(1972) - et al.
- et al.
J. Micros. (Paris)
(1968) - et al.
Immunology
(1959) - et al.
J. Exp. Med.
(1972) - et al.
New Eng. J. Med.
New Engl. J. Med.
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CD20 homo-oligomers physically associate with the B cell antigen receptor: Dissociation upon receptor engagement and recruitment of phosphoproteins and calmodulin-binding proteins
2008, Journal of Biological ChemistryCitation Excerpt :Furthermore, CD20 and sIgM are both characteristically expressed at diminished levels in malignant B cells from patients with chronic lymphocytic leukemia; in unusual chronic lymphocytic leukemia cases where the expression of sIgM is high, the expression of CD20 is also high (28). Coordinate expression of CD20 and the BCR, together with their colocalization on microvilli (14, 29, 30), their physical association as reported here, and the demonstrated involvement of CD20 in calcium influx downstream of BCR signaling (10, 11), suggests an important functional relationship that remains to be fully elucidated. Although CD20 has been linked to SOCE activated by BCR signals, humoral immune responses in CD20-deficient mice, at least to the antigens tested, appear to be normal (11, 31).
The CD20 calcium channel is localized to microvilli and constitutively associated with membrane rafts: Antibody binding increases the affinity of the association through an epitope-dependent cross-linking-independent mechanism
2004, Journal of Biological ChemistryCitation Excerpt :Consistent with this notion, the conformation of CD20 was recently shown to be sensitive to the level of membrane cholesterol, suggesting a potentially direct CD20-cholesterol interaction (27). The restricted distribution of CD20 on microvilli is consistent with its co-localization with the BCR (14), which is also found on microvilli, presumably to facilitate interaction with antigen (28, 29). In T cells, L-selectin also has microvillar localization and associates with rafts (30, 31).
Biological applications of photoelectron imaging: a practical perspective
1991, UltramicroscopyImmunoelectron microscopic studies on the cell surface location of the thyroid microsomal antigen
1987, Molecular and Cellular EndocrinologyPolymer microbeads in immunology
1987, Biomaterials
Supported by NIH Grant AI09719-03.