Platelet activating factor and leukotriene B4 induce hyperpolarisation of human endothelial cells but depolarization of neutrophils
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Effects of Platelet-Activating Factor on Brain Microvascular Endothelial Cells
2018, NeuroscienceCitation Excerpt :We also identified that PAF depolarized RBMVEC loaded with a slow response voltage-sensitive fluorescent dye, DiBAC4(3); the response was significantly diminished by antagonism of PAF receptor or by inhibition of Ca2+ influx. Similarly, earlier studies reported that PAF depolarized human or rabbit neutrophils (Naccache et al., 1986; Lerner et al., 1988) human platelets (Avdonin et al., 1991), bovine oviductal cells (Tiemann et al., 1999) or rat stomach fundus (Kamata et al., 1993a). Depolarization of vascular endothelial cells was associated with NO production and increased cellular stiffness via reorganization of cortical actin cytoskeleton (Callies et al., 2011).
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1994, Prostaglandins, Leukotrienes and Essential Fatty AcidsEndothelium-derived relaxing and contracting factors: Perspectives in nephrology
1991, Kidney InternationalThe role of platelet-activating factor in inflammation
1990, Clinical Immunology and ImmunopathologyLeukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils
1990, Biochemical and Biophysical Research Communications
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