Induction of indoleamine dioxygenase by interferon in mice: A study with different recombinant interferons and various cytokines

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Since it is important the availability of a specific marker for interferon induction in vivo, we investigated the effect of different recombinant interferons and various cytokines on indoleamine 2,3-dioxygenase activity. Although with different magnitude, recombinant interferon-α A/D (Bgl II) hybrid, interferon-γ and tumor necrosis factor, all increase the activity of this enzyme, whereas interleukin-1, recombinant interferon-α A and interferon-α D do not induce this activity in mice lung tissue. Dexamethasone is able to inhibit indoleamine 2,3-dioxygenase induction by lipopolysaccharide or by interferon-α A/D but it fails to prevent the induction by interferon-γ.

References (21)

  • HirataF. et al.

    Biochem. Biophys. Res. Commun.

    (1972)
  • HayaishiO. et al.

    J. Biol. Chem.

    (1977)
  • TaniguchiT. et al.

    J. Biol. Chem.

    (1977)
  • YoshidaR. et al.
  • YoshidaR. et al.

    Arch. Biochem. Biophys.

    (1986)
  • YoshidaR. et al.
  • YasuiH. et al.
  • OzakiY. et al.

    Biochem. Biophys. Res. Commun.

    (1987)
  • PfefferkornE.R.
  • Ozaki, Y., Edelstein, M.P., and Duch, D.S. Proc. Natl. Acad. Sci. USA in...
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