Exon-intron organization of a gene for pregnancy-specific β1-glycoprotein, a subfamily member of CEA family: Implications for its characteristic repetitive domains and C-terminal sequences

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A fragment of human gene for pregnacy-specific β1-glycoprotein(s), recently identified CEA family member(s), has been cloned. Analyses of nucleotide and deduced amino acid sequences revealed that it carried, from 5′ to 3′ direction, exons IA, IB, IIA, IIB, C3, C1 and C2, the first four encoding peptides distinct from but highly similar to domains of PSBGs. The lack of consensus 3′ splice site sequence ahead of IB indicated that it was an abortive exon,which would explain the peculiar domain construction of PSβGs, i.e. N-IA-IIA-IIB-C1, 2 or 3. Apparently, the multiple C-terminal sequences for a PSβGwere generated by alternative splicing among C1, C2 and C3 exons. Furthermore, sequences which overlapped partly with Cexons, were found to be similar to parts of 3′-UTR of CFA and NCA, indicating further the close relationship of CEA/NCA and PSβG subfamily genes.

References (20)

  • OikawaS. et al.

    Biochem. Biophys. Res. Commun.

    (1987)
  • OikawaS. et al.

    Biochem. Biophys. Res. Commun.

    (1987)
  • TawaragiY. et al.

    Biochem. Biophys. Res. Commun.

    (1988)
  • NeumaierM. et al.

    J. Biol. Chem.

    (1988)
  • OikawaS. et al.

    Biochem. Biophys. Res. Commun.

    (1987)
  • WatanabeS. et al.

    J. Biol. Chem.

    (1988)
  • WatanabeS. et al.

    Biochem. Biophys. Res. Commun.

    (1988)
  • StreydioC. et al.

    Biochem. Biophys. Res. Commun.

    (1988)
  • LawnR.M. et al.

    Cell

    (1978)
  • SouthernE.M.

    J. Mol. Biol.

    (1975)
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