SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine

doi:10.1016/0925-4927(94)90013-2

Psychiatry Research: Neuroimaging

Volume 55, Issue 4, December 1994, Pages 181-191

https://doi.org/10.1016/0925-4927(94)90013-2 Get rights and content

Abstract

The effects of naltrexone-precipitated withdrawal from buprenorphine on behavior and regional cerebral blood flow (rCBF) were studied in 11 opiate-dependent patients. Patients initially received buprenorphine, 2 mg sublingually, every day for 7 days. They were then challenged sequentially with placebo and naltrexone, 25 mg orally, before single photon emission computed tomography with technetium-⁹⁹m-d,l-hexamethyl-propylene amine oxime as tracer. Behavioral ratings of withdrawal severity were made before and after naltrexone/placebo administration. Naltrexone produced significantly greater signs and symptoms of opiate withdrawal than placebo. Analysis of variance revealed no significant regionally specific effect of naltrexone on rCBF ratios. Severity of withdrawal, however, showed a significant negative correlation with rCBF in the anterior cingulate cortex following naltrexone. These results are interesting as the anterior cingulate region has been implicated in the emotional component of pain and in opiate-induced analgesia.

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SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine

Abstract

Life Sciences

Life Sciences

Brain Research

Brain Research

Brain Research

Brain Research

Lancet

Neuroscience

Drug and Alcohol Dependence

Brain Research

Dienephalic mechanisms of pain sensation

Brain Research Reviews

Assessment of the arterial input curve for Tc-99m-d,l HM-PAO by rapid octonal extraction

Journal of Cerebral Blood Flow and Metabolism

Quantitative measurements of cerebral blood flow using SPECT and 99mTc-HMPAO compared to xenon-133

Journal of Cerebral Blood Flow and Metabolism

A clinical trial of buprenorphine: Comparison with methadone in the detoxification of heroin addicts

Clinical Pharmacology and Therapeutics

Pain reflief by frontal cingulotomy

Neurosurgery

Imaging opiate receptors in the human brain by positron tomography

Journal of Computer Assisted Tomography

In vivo tracer studies of glucose metabolism, cerebral blood flow and protein synthesis in naloxone precipitated morphine withdrawal

Neurochemistry Research

Cerebral blood flow during delirium tremens and related states studied with xenon-133 inhalation tomography

American Journal of Psychiatry

Brain perfusion SPECT using an annular single crystal camera: Initial clinical experience

Journal of Nuclear Medicine

Assessment of the arterial input curve for Tc-⁹⁹m-d,l HM-PAO by rapid octonal extraction

Quantitative measurements of cerebral blood flow using SPECT and ⁹⁹mTc-HMPAO compared to xenon-133