Synthesis, structural characterization, crystallographic analysis and antibacterial properties of some nitrofuryl triazolo[3,4-b]-1,3,4-thiadiazines

doi:10.1016/0223-5234(94)90100-7

European Journal of Medicinal Chemistry

Volume 29, Issue 4, 1994, Pages 301-308

https://doi.org/10.1016/0223-5234(94)90100-7 Get rights and content

Abstract

A series of 1-(5-nitro-2-furyl)-2-bromo-3-aryl-2-propen-1-ones has been prepared through dehydrobromination of 2,3-dibromo-1-(5-nitro-2-furyl)-3-arylpropan-1-ones. Condensation of 1-(5-nitro-2-furyl)-2-bromo-3-aryl-2-propen-1-ones with 4-amino-5-mercapto-1,2,4-triazoles afforded a new class of 6-(5-nitro-2-furyl)-7-arylidene-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. The structure of the condensation products are fully confirmed by analytical, IR, NMR and mass spectral data. The formation of 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines rather than 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazepines in the above condensation has also been confirmed by X-ray crystallographic analysis. The newly synthesized compounds have been screened for their in vitro antibacterial activity against Gram-positive and Gram-negative bacteria.

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^∗∗: deceased 1992.

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Preliminary communicationSynthesis, structural characterization, crystallographic analysis and antibacterial properties of some nitrofuryl triazolo[3,4-b]-1,3,4-thiadiazines

Abstract

Eur J Med Chem

Talanta

J Heterocycl Chem

J Heterocycl Chem

Il Farmaco

J Med Chem

J Med Chem

J Med Chem

Heterocycles

Heterocycles

Il Farmaco

Chem Pharm Bull

J Heterocycl Chem

J Med Chem

Preliminary communication
Synthesis, structural characterization, crystallographic analysis and antibacterial properties of some nitrofuryl triazolo[3,4-b]-1,3,4-thiadiazines