Chemistry & Biology
EditorialCrossing the boundaries
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The chemistry-biology-medicine continuum and the drug discovery and development process in academia
2014, Chemistry and BiologyCitation Excerpt :At the same time, chemists and biologists in academia began to recognize and appreciate the importance and potential impact of merging their efforts toward the elucidation of biological pathways and disease pathogenesis. This drive toward merging chemistry and biology gave birth to chemical biology (Schreiber and Nicolaou, 1994a, 1994b), an umbrella scientific discipline; one of the main areas of investigation of this domain is the synthesis and use of small organic molecules of natural or designed origins to probe human biology as a means to gain new fundamental knowledge and pave the way for drug discovery and development (Nicolaou, 2013, 2014b; Nicolaou and Montagnon, 2008; Schreiber, 2011; Wetzel et al., 2011). Tools to elucidate biological pathways and lead compounds for drug discovery are two of the most important objectives of organic synthesis and chemical biology today.
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