Biochimica et Biophysica Acta (BBA) - Biomembranes
H+-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics
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Evaluation of PepT1 transport of food-derived antihypertensive peptides, Ile-Pro-Pro and Leu-Lys-Pro using in vitro, ex vivo and in vivo transport models
2017, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :There is evidence of both paracellular and PepT1-mediated uptake of other di- and tripeptides, although there is debate on which route is of more significance [16,18,19]. Contribution of PepT1-mediated uptake can be determined in vitro in Caco-2 monolayers by saturating PepT1 with glycyl-sarcosine (Gly-Sar), a high affinity dipeptidyl competitive inhibitor and substrate [20,21]. A decrease in permeability in the presence of Gly-Sar suggests that the candidate peptide is a substrate for PepT1 [22,23].
Peptide and peptide analog transport systems at the blood-CSF barrier
2004, Advanced Drug Delivery ReviewsCitation Excerpt :This finding agrees with our general lack of knowledge concerning the cellular efflux mechanism of peptides/mimetics across the basolateral membrane of other epithelia (e.g., intestine and kidney). Notwithstanding this uncertainty, it has been shown in rat, human, and canine cell culture studies [27,178–181] that dipeptides, tripeptides, and peptidomimetics interact with basolateral transport systems that are distinct from currently known POT family members (i.e., PEPT1, PEPT2, PHT1, and PHT2). Ultimately, cloning should help to elucidate the precise nature of the basolateral peptide transporter in choroid plexus, as well as in other tissues.
Enhanced Permeability of Phenylalanyl-glycine (Phe-Gly) Across the Intestinal Membranes by Chemical Modiôcation with Various Fatty Acids
2003, Drug Metabolism and PharmacokineticsEffects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers
2002, European Journal of Pharmaceutical SciencesIdentification of a candidate membrane protein for the basolateral peptide transporter of rat small intestine
2002, Biochemical and Biophysical Research Communications