Metabolic effects of phenethyl alcohol on mammalian cells

https://doi.org/10.1016/0005-2787(67)90179-7Get rights and content

Abstract

In baby hamster kidney (BHK 21) cells, phenethyl alcohol interferes primarily with RNA synthesis. The effects of the compound on DNA and protein synthesis appear to derive from its primary effect on RNA metabolism. This conclusion was supported by the finding that phenethyl alcohol did not inhibit protein synthesis in rabbit reticulocytes which do not synthesize new RNA. The DNA isolated from phenethyl alcohol-treated cells was undegraded; this is at variance with the report of other investigators.

References (26)

  • J.C. Suit et al.

    Biochem. Biophys. Res. Commun.

    (1964)
  • F.R. Leach et al.

    Exptl. Cell Res.

    (1964)
  • M. Sekiguchi et al.

    J. Biol. Chem.

    (1963)
  • E.C. Henshaw et al.

    J. Mol. Biol.

    (1965)
  • R. Reeder et al.

    J. Mol. Biol.

    (1967)
  • F.M. Conconi et al.

    J. Mol. Biol.

    (1966)
  • C.C. Widnell et al.

    Biochim. Biophys Acta

    (1964)
  • T.H. Hamilton et al.

    Biochim. Biophys. Acta

    (1965)
  • R.H. Burdon et al.

    Biochim. Biophys. Acta

    (1961)
  • H.S. Rosenkranz et al.

    Biochem. Biophys. Res. Commun.

    (1964)
  • G. Berrah et al.

    J. Bacteriol.

    (1962)
  • H.S. Rosenkranz et al.

    J. Bacteriol.

    (1965)
  • E.Z.I. Khafagy et al.

    Biochim. Biophys. Acta

    (1966)
  • Cited by (0)

    View full text