Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein

doi:10.1016/0009-8981(88)90123-4

Clinica Chimica Acta

Volume 172, Issue 1, 29 February 1988, Pages 85-92

https://doi.org/10.1016/0009-8981(88)90123-4 Get rights and content

Abstract

We studied the effects of two substances related to acute inflammation, platelet activating factor (PAF) and C-reactive protein (CRP), on the chemiluminescence reaction of human neutrophils. PAF caused chemiluminescence dosedependently when calcium ion was present. This luminescence was inhibited competitively by CV-3988, a structural analogue of PAF. However, when CRP, an indicator of inflammation, was added, the luminescence reaction was inhibited. The findings suggested that CRP neutralizes the action of PAF in acute inflammation.

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Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein

Abstract

Adv Immunol

Biochem Biophys Res Commun

Biochem Biophys Res Commun

J Biol Chem

Blood

Biochem Biophys Res Commun

Biochim Biophys Acta

Blood

Biochem Biophys Res Commun

Perspectives in platelet-activating factor in research

Pharmacol Rev

Selective desensitization of neutrophils; Further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues

J Immunol

Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-actyl-sn-glycero-3-phosphorylcholine (platelet activation factor)

J Immunol