High concentrations of immunoreactive gliostatin/platelet-derived endothelial cell growth factor in synovial fluid and serum of rheumatoid arthritis
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2018, Bioorganic ChemistryCitation Excerpt :If uncontrolled, then a complex series of events start, eventually ending up in the tumour growth [1–7]. In addition to its role in cancers, the hyper proliferation due to over-expressed TP have been also been found in diseases like rheumatoid arthritis and psoriasis, which is again attributed to its angiogenic activity [8]. These factors are in turn involved in many sub-processes like proliferation of endothelial cells due to metalloproteinase and formation of new blood vessels in tumour tissues, thus supporting the cancer metastasis.
The influence of elevated levels of platelet-derived endothelial cell growth factor/thymidine phosphorylase on tumourigenicity, tumour growth, and oxygenation
1998, International Journal of Radiation Oncology Biology PhysicsThe Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes
2012, Arthritis Research and Therapy
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