An in vivo phosphorus nuclear magnetic resonance study of the variations with age in the phosphodiers' content of human muscle

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Abstract

Human gastrocnemius and slow twitch muscles contain phosphodiesters that may be detected in vivo by phosphorus nuclear magnetic resonance (NMR). This work represents a study of 354 spectra obtained from healthy subjects of various ages and from patients with peripheral vascular disease. The analysis of the data indicate a correlation between the concentration of phosphodiesters and age. By comparing the data obtained with healthy subjects and patients it is concluded that the increase in phosphodiesters is not due to disease, but to ageing itself. The significance of this increase is discussed.

References (26)

  • B. Chance et al.

    Mitochondrial regulation of phosphocreatine/inorganic phosphate ratios in exercising human muscle: a gated 31P NMR study

  • B. Chance et al.

    31P NMR studies of control of mitochondrial function in phosphofructokinase-deficient human skeletal muscle

  • S. Eleff et al.

    31P NMR study of improvement in oxidative phosphorylatin by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle

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