Antagonistic effect of KC-404, a new anti-asthmatic agent, on leukotriene D4-induced contractile responses in isolated guinea pig smooth muscles
References (37)
- et al.
Slow-reacting substance of anaphylaxis
Adv. Immunol.
(1969) - et al.
Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity
Biochem. Biophys. Res. Commun.
(1980) - et al.
The effect of leukotrienes C4 and D4 on the micro- vasculature of guinea-pig skin
Prostaglandins
(1981) - et al.
KC-404: A potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis
Japan. J. Pharmacol.
(1983) - et al.
Biological activities of a chemically synthesized form of leukotriene E4
Prostaglandins
(1981) - et al.
Peptidoleukotrienes: Distinct receptors for leukotriene C4 and D4 in the guinea-pig lung
Biochem. Biophys. Res. Commun.
(1983) - et al.
Contraction of isolated airway smooth muscle by synthetic leukotrienes C4 and D4
Prostaglandins
(1981) - et al.
Evidence for multiple leukotriene D4 receptors in smooth muscle
Life Sci.
(1982) - et al.
Pharmacologic receptors for the leukotrienes
Biochem. Pharmacol.
(1984) - et al.
Effect of the serine-borate complex on the relative ability of leukotriene C4, D4 and E4 to inhibit lung and brain [3H] leukotriene D4 and [3H] leukotriene C4 binding: Demonstration of the agonists' potency order for leukotriene D4 and leukotriene C4 receptors
Biochem. Biophys. Res. Commun.
(1984)
The mechanism of action of leukotrienes C4 and D4 in guinea-pig isolated perfused lung and parenchymal strips of guinea-pig, rabbit and rat
Prostaglandins
(1981)
Pharmacological studies on newly synthesized anti-allergic agents, 2-methyl-3-piperidino-β-propionaphthone hydrochloride (KZ-111) and 3-isobutyryl- 2-isopropylpyrazolo [1,5-a]pyridine (KC-404)
Japan. J. Pharmacol.
(1983)
Subcellular fractions of smooth muscle. Isolation, substrate utilization and Ca++ transport by main pulmonary artery and mesenteric vein mitochondria
Arch. Biochem. Biophys.
(1975)
The actions of D600, Aspaminol and papaverine on calcium-. potassium- and histamine-induced contractions of isolated rabbit basilar artery, aorta, taenia coli and tracheal smooth muscle
Japan. J. Pharmacol.
(1983)
Homeostasis of effector systems which can also be recruited for immunologic reactions
J. Immunol.
(1978)
Characterization of slow-reacting substances (SRSs) of rat basophilic leukemia (RBL-1) cells: Effect of cysteine on SRS profile
SRSA-mediated bronchospasm by pharmacologic modification of lung anaphylaxis in vivo
Agents Actions
(1981)
Airway sensitivity to slow-reacting substances of anaphylaxis, histamine, and antigen in Ascaris sensitive monkeys
Am. Rev. Respir. Dis.
(1979)
Cited by (23)
Preferential inhibition of human phosphodiesterase 4 by ibudilast
2006, Life SciencesInhibitory effect of ibudilast (KC-404) on the expression of the β<inf>2</inf> integrin family on an eosinophilic cell line (EoL-1)
1998, Annals of Allergy, Asthma and ImmunologyRelaxation and potentiation of cGMP-mediated response by ibudilast in bovine tracheal smooth muscle
2002, Naunyn-Schmiedeberg's Archives of PharmacologyIbudilast: A non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall
2001, Cardiovascular Drug Reviews
Copyright © 1987 Published by Elsevier Inc.