ArticleEffects of an ACTH/MSH(4–9) analog (HOE 427) on the sleep EEG and nocturnal hormonal secretion in humans☆
References (38)
- et al.
The effects of ACTH, adrenalectomy and dexamethasone on the acquisition of an avoidance response in rats
Physiol. Behav.
(1970) - et al.
Pilocarpine, an orally active muscarinic cholinergic agonist, induces REM sleep and reduces delta sleep in normal volunteers
Psychiatry Res.
(1990) - et al.
Influences of ACTH 4–10 on event-related potentials reflecting attention in man
Physiol. Behav.
(1987) - et al.
How ACTH acts on the brain
Biobehav. Rev.
(1977) - et al.
Potency and duration of action of the ACTH4–9 analog (ORG 2766) as compared to ACTH4–10 and (D-Phe7) ACTH4–10 on active and passive avoidance behavior of rats
Pharmacol. Biochem. Behav.
(1982) - et al.
The ACTH-(4–9) analog ORG 2766 and desglycinamide9-(Arg8)-vasopressin reverse the retrograde amnesia induced by disrupting circadian rhythms in rats
Peptides
(1986) - et al.
Learning and memory processes of an ACTH4–9 analog (ebiratide; HOE 427) in mice and rats
Peptides
(1988) - et al.
Pre- and postnatally administered ACTH, organon 2766 and CRF facilitate or inhibit active avoidance task performance in young adult mice
Peptides
(1988) - et al.
Behavioral aspects of melanocyte-stimulating hormone (MSH)
- et al.
Peripheral administration of hypothalamic peptides result in CNS changes
Pharmacol. Res. Commun.
(1978)
Additional evidence that small amounts of a peptide can cross the blood barrier
Pharmacol. Biochem. Behav.
A synthetic ACTH 4–9 analogue (organon 2766) and sleep in healthy man
Neuropharmacology
Neurotrophic ACTH analogue promotes plasticity of type I corticosteroid receptor in brain of senescent male rats
Neurobiol. Aging
Effects of two ACTH analogs on successive odor discrimination learning in rats
Peptides
Enhancement of attention in man with ACTH/MSH4–10
Physiol. Behav.
Are learning and attention related to the sequence of amino acids on ACTH/MSH peptides?
Peptides
Beneficial effect of an ACTH-(4–9) analog on peripheral neuropathy and blood pressure response to tyramine in streptozocin diabetic rats
Eur. J. Pharmacol.
Neurochemical effects of the synthetic ACTH4–9-analog HOE 472 (ebiratide) in rat brain
Peptides
The cholinergic rapid eye movement sleep induction test with RS-86
Arch. Gen. Psychiatry
Cited by (38)
Endocrinology of sleep
2023, Encyclopedia of Sleep and Circadian Rhythms: Volume 1-6, Second EditionStress & sleep: A relationship lasting a lifetime
2020, Neuroscience and Biobehavioral ReviewsCitation Excerpt :In young male volunteers, sleep electroencephalographic (EEG) activity changes occurred after pulsatile intravenous administration of ebiratide, an ACTH analog. Specifically, in these subjects NREM sleep decreased whereas sleep latency and wakefulness increased during the first third of the night (Steiger et al., 1991). In intact cats, ACTH infusions suppressed REM sleep (Koranyi et al., 1971) and, in rats, it significantly increased sleep latency and wake time while decreasing NREM sleep time (Tsutsui et al., 2015).
Effect of 5-HT2A receptor polymorphisms and occupational stress on self-reported sleep quality: A cross-sectional study in Xinjiang, China
2016, Sleep MedicineCitation Excerpt :Various studies have also investigated the relationships between sleep quality and activation of the hypothalamic–pituitary–adrenal (HPA) axis, which is the major neuroendocrine system regulating stress responses via modulation of cortisol, adrenocorticotropic hormone (ACTH), and corticotropin-releasing hormone (CRH) levels [36]. CRH and ACTH infusion reduced slow-wave sleep during the sleep period and rapid eye movement (REM) during part of the sleep cycle, and also increased sleep latency [37,38], implying that stress perturbs normal sleep via HPA axis activation. Indeed, in the present study, subjects with high occupational stress – encompassing occupational role and personal strain – were at greater risk of poor sleep quality than those with low or moderate stress in both univariate and multivariate logistic regression analyses.
Neurochemical regulation of sleep
2007, Journal of Psychiatric ResearchCitation Excerpt :The synthetic ACTH (4–9) analogue ebiratide shares several behavioural effects of ACTH but does not influence peripheral hormone secretion. Accordingly after repetitive i.v. ebiratide, GH and cortisol remain unchanged in young male controls, sleep onset increases, and during the first third of the night awake time is elevated and SWS decreases (Steiger et al., 1991). This observation corroborates the view that the blood–brain interface is no obstacle for CNS effects of i.v. administered neuropeptides, as ebiratide induces sleep-EEG changes in the absence of effects on peripheral hormone secretion.
Peptides And Sleep
2006, Handbook of Biologically Active PeptidesInhibition of NF-κB activity by plasmid expressed αMSH peptide
2002, Journal of Neuroimmunology
- ☆
Parts of this study were presented at the 10th Congress of the European Sleep Research Society, Strasbourg, May 20–25, 1990.