Articleβ-Endorphin content in HIV-infected HuT78 cell line and in peripheral lymphocytes from HIV-positive subjects
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Evaluation of the adjuvant activity of naloxone, an opioid receptor antagonist, in combination with heat-killed Listeria monocytogenes vaccine
2010, Microbes and InfectionCitation Excerpt :The shift to a Th1 pattern plays an important role in the induction of cellular immunity [1]. Previous work has shown that the concentration of β-endorphin, an endogenous opioid in peripheral blood mononuclear cells, increases under conditions in which the Th2 cytokine pattern prevails, such as in cells obtained from human immunodeficiency virus (HIV)-positive subjects [24]. Sacerdote and colleagues have shown that both acute and chronic NLX administration skew the immune system toward a Th1 response [16].
Buprenorphine and methadone maintenance treatment of heroin addicts preserves immune function
2008, Brain, Behavior, and ImmunityCitation Excerpt :Studies on heroin addicts have repeatedly shown that the opioid consistently causes immunosuppression (Friedman et al., 2003; Neri et al., 2005; Donahoe and Vlahov, 1998). While the large percentage of infections among injecting drug users is partially related to injection methods and life-style practices, it is now accepted that heroin-induced immunosuppression may contribute as cofactor for several microbial infections, possibly enhancing the progression to AIDS in HIV infected individuals (Barcellini et al., 1994; Friedman et al., 2003; Ugen and Nyland, 2007). On the other hand, both preclinical and clinical studies appear to indicate that not all opioid receptor agonists share the same immunosuppressive properties (Sacerdote, 2006).
β-endorphin in the immune system: A role at last?
1997, Immunology Today