Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene
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Cathepsin B in human myometrium and in uterine leiomyomas at various stages of tumour growth
2015, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :The most intensive double band of 27/28 kDa corresponds to heavy chain of the fully processed double-chain enzyme form (hc-CATB), which was or was not glycosylated [17]. The trace forms of procathepsin B (pro-CATB; 41–45 kDa) are similar to those of the recombinant zymogen expressed in mammalian cells (43/45-kDa) [18], or may be a product of less intensive glycosylation (41 kDa), as pro-CATB has 3 potential attachment sites for N-linked oligosaccharides [19]. An additional minor band of 37 kDa presents lower mobility than in the case of the single-chain form of the enzyme, which typically migrates between 31 kDa [17,20,21] and 33 kDa [8,22].
Cathepsin b
2007, xPharm: The Comprehensive Pharmacology ReferenceClinicopathologic significance of cystatin C expression in gliomas
2005, Human PathologyMolecular cloning and analysis of stage and tissue-specific expression of cathepsin B encoding genes from Fasciola gigantica
2004, Molecular and Biochemical ParasitologyCitation Excerpt :Identities between the clones ranged from 64 to 79% (Table 2). Alignment of the cathepsin B amino acid sequences showed that the thiol consensus pattern (Gln-X(3)-[Gly, Glu]-X-Cys-Trp-X(2)-[Ser, Thr, Ala, Gly]), where X is any amino acid residue, and the active site residues (Cys29, His200, Asn220, human cathepsin B numbering) are highly conserved in the sequences of F. gigantica cathepsin B (Fig. 1) [14,16,19–21]. An occluding loop (residues 104–127, human cathepsin B numbering) and 12 cysteine residues forming disulfide bridges are also conserved in all three cathepsin B proteins.
A 72-Base Pair AT-rich DNA Sequence Element Functions as a Bacterial Gene Silencer
2001, Journal of Biological ChemistryCitation Excerpt :pWU812T was derived from pWU802T. To construct pWU812T, a 320-bp promoterless non-AT-rich (47% A+T) DNA was generated by polymerase chain reaction (PCR) from the coding region of human cathepsin B gene (19), with the primers introducing HincII andBstXI sites at the ends. The digestedHincII-BstXI fragment was then used to replace the 318-bp HincII-BstXI segment containing the native AT-rich sequence (69% A+T) between the divergently transcribing ptac and pleu-500 in pWU802T.
A polymorphic marker for the human cathepsin B gene
2001, Molecular and Cellular Probes