Regulation of adrenal functionInhibition of steroidogenesis in rat adrenal cortex cells by a threonine analogue
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Cantharidin and norcantharidin inhibit caprine luteal cell steroidogenesis in vitro
2012, Experimental and Toxicologic PathologyCitation Excerpt :Both cantharidin and norcantharidin have potential clinical utility as inhibitors of protein phosphatase 1 and 2A (PP1, PP2A) (McCluskey et al., 2003). The possibility that phosphatases might influence secretory processes has also attracted attention recently, and phosphatase-linked mechanisms have been implicated extensively in several endocrine tissues, including islets of langerhans and chromaffin and pituitary cells (Gagliardino et al., 1991; Green and Orme-Johnson, 1991; Iriuchijima et al., 1992; Polettini et al., 1992; Abayasekara et al., 1996; Murphy and Jones, 1996; Ciereszko et al., 2001). Both cantharidin and norcantharidin have been used to assess the role of phosphatases in steroidogenesis (Abayasekara et al., 1996; Ciereszko et al., 2001).
Steroidogenic acute regulatory protein expression is dependent upon post-translational effects of cAMP-dependent protein kinase A
2001, Molecular and Cellular EndocrinologySteroidogenic Acute Regulatory Protein
1998, Vitamins and HormonesNeuropeptide-induced inhibition of steroidogenesis in crab molting glands: Involvement of cGMP-dependent protein kinase
1996, General and Comparative Endocrinology