Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Regular paperArachidonate 5-lipoxygenase of porcine pancreas: its localization in acinar cells
References (25)
- et al.
J. Biol. Chem.
(1989) Prostaglandins Leukotrienes Ess. Fatty Acids
(1989)- et al.
J. Biol. Chem.
(1987) - et al.
J. Biol. Chem.
(1983) - et al.
Prostaglandins
(1988) - et al.
J. Biol. Chem.
(1988) - et al.
J. Biol. Chem.
(1986) - et al.
J. Biol. Chem.
(1983) - et al.
J. Biol. Chem.
(1951) - et al.
J. Biol. Chem.
(1986)
Biochem. Biophys. Res. Commun.
Biochim. Biophys. Acta
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Acinar Cell Production of Leukotriene B<inf>4</inf> Contributes to Development of Neurogenic Pancreatitis in Mice
2015, Cellular and Molecular Gastroenterology and HepatologyCitation Excerpt :Very little is known about leukotriene production in the pancreas. It was previously been shown by others that porcine34 and human22 pancreatic acinar cells express 5-LO and can synthesize LTB4. In addition, the human pancreas also expresses FLAP,35 but no information was available about the distribution of 5-LO in the mouse pancreas or the effects of inflammatory agents on pancreatic 5-LO activity.
5-Lipoxygenase and leukotriene B<inf>4</inf> receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue
2002, American Journal of PathologyCitation Excerpt :Immunohistochemistry studies have only shown the 5-LOX expression in porcine pancreatic acinar cells but not in porcine Langerhans islets or ductal cells.25 Staining was localized along the nuclear membranes of the acinar cells, demonstrated by immunoelectron microscopy.25 5-LOX expression and distribution was also investigated in rat pancreas, but no evidence of 5-LOX antigen or enzymatic activity was found in exocrine pancreas, purified β-cells, or other islet cells.39
Molecular Biology in the Eicosanoid Field
1993, Progress in Nucleic Acid Research and Molecular BiologyMammalian lipoxygenases: molecular structures and functions
1992, Biochimica et Biophysica Acta (BBA)/Lipids and Lipid MetabolismRole of lipoxygenase pathways in the regulation of pancreatic cancer cell proliferation and survival
2001, Inflammopharmacology