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2013, Chemistry and Physics of LipidsCitation Excerpt :Lateral diffusion of the lipid and protein components of biological membranes reflects this mosaic quality of biological membranes. Indeed, the ever increasing sophistication of our knowledge of biomembrane organization and functional segregation is due, in large measure, to the increasing sophistication of the experimental tools available for examining lateral diffusion (Jovin and Vaz, 1989; Glaser, 1993; Albertsson, 1995; Somerharju et al., 1999; Vaz and Melo, 2001; Lommerse et al., 2004; Day and Kenworthy, 2009). The most widely used techniques for measuring lateral diffusion are fluorescence-based.
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2009, Biophysical JournalCharacterization of physical properties of supported phospholipid membranes using imaging ellipsometry at optical wavelengths
2007, Biophysical JournalCitation Excerpt :Although such spreading kinetics can be gathered using fluorescence microscopy, quantitative applications of these measurements have met with limitations primarily because of the complex relations between the fluorescence intensities and the lipid environment, which is continuously evolving during the bilayer formation (37). Third, the issues of lateral heterogeneity and phase separation in multicomponent membranes are of considerable importance in understanding how molecular distributions influence localization of many generic membrane processes of great biological relevance (38–40). Fluorescence-based methods, utilizing phase-sensitive probes, have proven very useful in quantifying coexisting phases, but the role of labeled molecules in perturbing the natural phase separation of primary lipids remains ill-understood (41–43).
Characterization of two oxidatively modified phospholipids in mixed monolayers with DPPC
2006, Biophysical JournalCitation Excerpt :The fluid mosaic model (5) described biomembranes mainly as a diffusion barrier and a structural matrix embedding the active molecules, peripheral and integral membrane proteins, and covalently linked complex carbohydrates. Yet, it has become evident that biomembranes possess a considerable degree of static and dynamic heterogeneity because of i), the large number of different lipid species; and ii), their liquid crystalline nature (1,6–9). Furthermore, the lateral organization and the thermodynamic state of biomembranes determined by their lipids have been suggested to be correlated to the physiological functional states of cells (1), determining, e.g., protein-lipid interactions, further controlling the activity of membrane associated enzymes, for instance (2,3,10–16).