Gas chromatographic—mass spectrometric analysis of organic acids in renal tissue biopsy : Identification of 4-hydroxybutyric acid and 4-hydroxy-2-butenoic acid

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Abstract

The organic acids in renal tissue biopsy (0.5–1 mg) obtained from chronic glomerulonephritic patients were analyzed by capillary column gas chromatography—mass spectrometry. Some twenty compounds were identified in the renal tissue. The organic acid profile of renal tissue showed a marked difference from those of urine and serum. In particular, 4-hydroxybutyric acid and 4-hydroxy-2-butenoic acid, which are usually undetectable in urine and serum, were detected for the first time in renal tissue in considerably large amounts.

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