Journal of Chromatography B: Biomedical Sciences and Applications
High-performance liquid chromatographic determination of rutaecarpine in rat plasma: application to a pharmacokinetic study
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2021, Biochemistry and Biophysics ReportsCitation Excerpt :Further experiment will be needed to rule out this possibility. Rutaecarpine is rather hydrophobic but has a high hepatic extraction ratio (CL = 63 mL/min/kg in rats) [19]. Low rutaecarpine oral bioavailability could be due to high gut and/or liver first-pass effect.
Rutaecarpine administration inhibits cancer cell growth in allogenic TRAMP-C1 prostate cancer mice correlating with immune balance in vivo
2021, Biomedicine and PharmacotherapyCitation Excerpt :After oral administration of the same concentration of 40 mg Rut/kg b.w. in SD rats for 18 days, the Cmax value (≥ 22.8 ± 4.4 ng/mL) of the Rut purity group was higher than that in the crude drug (2.4 ± 0.3 ng/mL), indicating that the herbal extract can increase the bioavailability of Rut in SD rats [52,53]. Moreover, the values of T1/2, volume and AUC0-t in the plasma of Rut by intravenously administrated to the rats were 29.29 min, 655.15 mL/kg, and 32.93 µg min/mL, respectively [54]. Rut’s pharmacokinetic values may be helpful to its use in biomedicine and pharmacotherapy.
Traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the fruit of Tetradium ruticarpum: A review
2020, Journal of EthnopharmacologyGenus Tetradium L.: A comprehensive review on traditional uses, phytochemistry, and pharmacological activities
2019, Journal of EthnopharmacologyCitation Excerpt :Ruteacarpine (7) was intravenously administrated to rats to determine the pharmacokinetic parameters in the plasma of rats. The values of T1/2, CL, volume, and area under the curve (AUC) were 29.29 min, 63.46 mL/min kg, 655.15 mL/kg, and 32.93 µg/min·mL, respectively (Ko et al., 1994). Ruteacarpine (7) was reported to induce activities of CYP 1A2, 2E1, and 2B in rats, in addition to pharmacokinetic parameters of several compounds (e.g., acetaminophen and caffeine) (Noh et al., 2011; Sang et al., 2007).
Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility
2017, Bioorganic and Medicinal Chemistry Letters