Elsevier

Theriogenology

Volume 19, Issue 6, June 1983, Pages 771-778
Theriogenology

Effect of vehicle on intrauterine absorption of gentamicin in cattle☆

https://doi.org/10.1016/0093-691X(93)90320-5Get rights and content

Abstract

An intrauterine (IU) infusion of 4 ml gentamicin solution (G) was administered in a water vehicle to 4 normal cycling and healthy cows and in a saline vehicle to 4 other cows during the diestrous phase (days 7–14) of the cycle. Infusion solution (IS) and blood samples were collected periodically postinfusion. G concentration was determined in plasma and IS by radioimmunoassay. Eighty-three and 18% of the infused G disappeared from the uterine lumen by 6 hours postinfusion on using water and saline vehicles, respectively.

Total amounts of G reaching the blood stream were nearly the same during the 6 hours postinfusion period using water and saline vehicles. This suggested the possibility of retention of drug in uterine tissue using the distilled water vehicle.

References (4)

  • G. Ziv

    Review of pharmacology of antimicrobial drugs employed in veterinary obstetrics

  • G. Ziv

    Clinical pharmacology of antibacterial drugs and their application in treating bovine metritis

There are more references available in the full text version of this article.

Cited by (0)

☆

Gentamicin has not been approved by the U.S. Food and Drug Administration for use in food producing animals.

(b)

Colonel Dr. Sayed A. Al-Guedawy Military Veterinary Service Administration Ministry of Defense and Armed Forces, Cairo, Egypt Address: 6 Yossif el-Degwy Street Mamal el Rouda Cairo, Egypt

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