Abstract
After V(D)J-mediated translocations, signal joints are retained on one of the derivative chromosomes. We report here that such signal joints are highly reactive and constitute unstable genomic elements with potential oncogenic properties.
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Acknowledgements
We thank P. Ferrier, A.W. Langerak, J.J.M van Dongen and F. McBlane for comments and discussions and E. Hayden for help with the statistical analysis. This work was supported by the Center of Molecular Medicine of the Austrian Academy of Sciences.
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Marculescu, R., Vanura, K., Le, T. et al. Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL. Nat Genet 33, 342–344 (2003). https://doi.org/10.1038/ng1092
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DOI: https://doi.org/10.1038/ng1092
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