Though several technical hurdles remain, effective and reliable genetic tests for multigene diseases should be available within the next five years.
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References
Chang, J.C. and Kan, Y.W. 1982. N. Engl. J. Med. 307: 30–32.
Friend, S.H. et al. 1986. Nature 323: 643–646.
Toguchida, J. et al. 1988. Cancer Res. 48: 3939–3943.
Blanquet, V. et al. 1995. Hum. Mol. Genet. 4: 383–388.
Liu, Z., Song, Y., Bia, B.., and Cowell, J.K. 1995. Genes Chrom. Cancer 14: 277–284.
Lohmann, D.R., Brandt, B., Höpping, W., Passarge, E., and Horsthemke, B. 1996. Am. J. Hum. Genet. 58: 940–949.
Lohmann, D.R., Brandt, B., Höpping, W., Passarge, E., and Horsthemke, B. 1994. Hum. Genet. 94: 349–354.
Lohmann, D.R., Brandt, B., Hopping, W., Passarge, E., and Horsthemke, B. 1994. Hum. Mol. Genet. 3: 2187–2193.
Noorani, H.Z., Khan, H.N., Gallie, B.L., and Detsky, A.S. 1996. Am. J. Hum. Genet. 59: 301–307.
Brown, M.L. and Kessler, L.G. 1996. Int. J. Cancer 69: 55–57.
Miki, Y. et al. 1994. Science 266: 66–71.
Lerman, C. et al. 1996. J. Am. Med. Assoc. 275: 85–1892.
Abbott, A. 1996. Nature 379: 390.
Collins, F.S. 1995. N. Engl. J. Med. 334: 186–188.
Wooster, R. et al. 1995: Nature 378: 789–792
Tavtigian, S.V. et al. 1996. Nature Genet. 12: 333–337.
Tonin, P. et al. 1996. Nature Med. 2: 117–1183.
Sidransky, D. et al. 1992. Cancer Res. 52: 2984–2986.
Savitsky, K. et al. 1995. Hum. Mol. Genet. 4: 2025–2032.
Liaw, D. et al. 1997. Nature Genet. in press.
Fishel, R. and Kolodner, R.D. 1995. Curr. Opin. Genet. Dev. 5: 382–395.
Stern, H.J., Carlos, R.D., and Schuzbank, T.E. 1995. Clin. Biochem. 28: 470–473.
Sanger, F., Nicklen, S., and Coulson, A.R. 1977. Proc. Natl. Acad. Sci. USA 74: 5463–5467.
Chetverin, A.B. and Russell Kramer, F. 1994. Bio/Technology 12: 1093–1099.
Beattie, W.G. et al. 1995. Mol. Biotechnol. 4: 213–225.
Kozal, M.J. et al. 1996. Nature Med. 2: 753–759.
Chee, M. et al. 1996. Science 274: 610–614.
Hacia, J.G., Brody, L.C., Chee, M.S., Fodor, S.P.A., and Collins, F.S. 1996. Nature Genet. 14: 441–447.
Liu, B. et al. 1994. Cancer Res. 54: 4590–4594.
Liu, B. et al. 1996. Nature Med 2: 169–173.
FitzGerald, M.G. et al. 1996. N. Engl. J. Med. 334: 143–149.
Xia, L. et al. 1996. Cancer Res. 56: 2289–2292.
Phelan, C.M. et al. 1996. Nature Genet. 13: 120–122.
Couch, F.J. et al. 1996. Nature Genet. 13: 123–128.
Orita, N., Iwahana, H., Kanazawa, H., Hayashi, K., and Sekiya, T. 1989. Proc. Natl. Acad. Sci. USA 86: 2766–2770.
Liu, Q. and Sommer, S.S. 1995. BioTechniques 18: 470–477.
Sarkar, G., Yoon, H.-S., and Sommer, S.S. 1992. Genomics 13: 441–443.
Mashal, R.D., Koontz, J., and Sklar, J. 1995. Nature Genet. 9: 177–183.
Youil, R., Keker, B.W., and Cotton, R.G.H. 1995. Proc. Natl. Acad. Sci. USA 92: 87–91.
Fischer, S.G. and Lerman, L.S. 1979.Cell 16: 191–200.
Lerman, LS. and Silverstein, K. 1987. Methods Enzymol. 155: 482–501.
Guldberg, P., Henriksen, K.F., and Guttler, F. 1993. Genomics 17: 141–146.
van Orsouw, N. et al. 1996. Hum. Mol. Genet. 5: 755–761.
Wu, Y., et al 1996. Hum. Mutat. 8: 160–167.
Nystrom-Lahti, M. et al. 1996. Hum. Mol. Genet 5: 763–769.
Wu, Y. et al. 1997. Genes, Chrom, Cancer, in press.
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Eng, C., Vijg, J. Genetic testing: The problems and the promise. Nat Biotechnol 15, 422–426 (1997). https://doi.org/10.1038/nbt0597-422
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DOI: https://doi.org/10.1038/nbt0597-422
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