Abstract
SEVERAL reports have appeared recently regarding the effect of various halogenatedpyrimidines on herpes simplex virus1–3. 5-Iodo-2′-deoxyuridine (IUDR) and 5-fluoro-2′-deoxyuridine inhibit the herpes simplex virus growth, both in vitro and in vivo. These halogenated pyrimidines inhibit the biosynthesis of deoxyribonucleic acid by competing with thymidine in the synthesis of DNA-thymidine in mouse Ehrlich ascite cells.
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References
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LODDO, B., MUNTONI, S. & FERRARI, W. Effect of 5-iodo-2′-deoxyuridine on Vaccinia Virus, in vitro. Nature 198, 510 (1963). https://doi.org/10.1038/198510a0
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DOI: https://doi.org/10.1038/198510a0
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