Abstract
SYNTHETIC peptides prepared by Hofmann and associates1 containing 8, 10 or 13 amino-acids identical in sequence with the N-terminal portion of corticotropin were tested for adipokinetic activity because corticotropin was known to have this activity2–4. The tridecapeptides caused the release of free fatty acids by adipose tissue; the decapeptides were also active but less potent, but the octapeptide had no effect in the amounts tested.
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References
Hofmann, K., Yajima, H., and Schwartz, E. T., J. Amer. Chem. Soc. (in the press).
Rosenberg, I. N., Proc. Soc. Exp. Biol. Med., 82, 701 (1953).
White, J. E., and Engel, F. L., J. Clin. Invest., 37, 1556 (1958).
Hollenberg, C. H., Raben, M. S., and Astwood, E. B., Endocrinology (in the press).
Waller, J.-P., and Dixon, H. B. F., Biochem. J., 75, 320 (1960).
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RABEN, M., LANDOLT, R., SMITH, F. et al. Adipokinetic Activity of Synthetic Peptides Related to Corticotropin. Nature 189, 681–682 (1961). https://doi.org/10.1038/189681a0
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DOI: https://doi.org/10.1038/189681a0
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