Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Inhibitory Actions of γ-Aminobutyrylcholine

Nature volume 185, pages 848–849 (1960)Cite this article

Abstract

SINCE the existence of γ-aminobutyrylcholine in the mammalian brain and the possibility of its being a neurotransmitter have been reported1, new findings on this substance have been reported by several investigators. Takahashi et al. 2 noticed its inhibitory effect on the electrical activity of the brain. McLennan3 found that the second active ingredient of his factor 1 can be accounted for by this compound biologically but not chromatographically; and Kewitz4 claims to have isolated γ-aminobutyrylcholine in crystalline form from the brain of the pig. In view of its anticholinergic and antihistaminic activities1, we thought it worth while to study further its inhibitory properties on some other preparations.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kuriaki, K., Yakushiji, T., Noro, T., Shimizu, T., and Saji, Sh., Nature, 181, 1336 (1958).

    Article  ADS  CAS  Google Scholar 

  2. Takahashi, H., Nagashima, A., and Koshino, Ch., Nature, 182, 1443 (1958).

    Article  ADS  CAS  Google Scholar 

  3. McLennan, H., J. Physiol., 146, 258 (1959).

    Article  Google Scholar 

  4. Kewitz, H., Naturwiss., 46, 495 (1959).

    Article  ADS  CAS  Google Scholar 

  5. Yoshihara, H., and Kuriaki, K., C.R. Soc. Biol., 151, 1462 (1957).

    CAS  Google Scholar 

  6. Florey, E., Canad. J. Biochem. and Physiol., 34, 669 (1956).

    Article  CAS  Google Scholar 

  7. Florey, E., and McLennan, H., J. Physiol., 129, 384 (1955).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. M. ASANO

    Present address: Department of Physiological Hygiene, Institute of Public Health, Shiba Sirogane Daimachi, Minato-ku, Tokyo

Authors and Affiliations

  1. Department of Pharmacology, Nippon Medical School, 59 Sendagicho, Bunkyo-ku, Tokyo

    M. ASANO, T. NORO & K. KURIAKI

Authors
  1. M. ASANO
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. NORO
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. KURIAKI
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

ASANO, M., NORO, T. & KURIAKI, K. Inhibitory Actions of γ-Aminobutyrylcholine. Nature 185, 848–849 (1960). https://doi.org/10.1038/185848a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/185848a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing