Abstract
IT has previously been reported1,2 that chlorothiazide and its saturated derivative, hydrochlorothiazide, have a substantial and sustained antidiuretic effect in diabetes insipidus, both experimental and clinical. The antidiuretic activity of unit weight of hydrochlorothiazide, and of its trifluoromethyl and benzyltrifluoromethyl analogues (hydrofluomethiazide and FT81), is many times greater than that of chlorothiazide.
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KENNEDY, G., CRAWFORD, J. An Antimineralocorticoid Action of some Saluretic Sulphonamides. Nature 184, 1492–1493 (1959). https://doi.org/10.1038/1841492a0
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DOI: https://doi.org/10.1038/1841492a0
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