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Chemotherapy of T. congolense Infections with Phenanthridine Compounds : Biological Aspects

Abstract

IN the editorial article, "Sleeping Sickness and Nagana" (Nature January 15), mention is made of phenanthridine compounds in the treatment of cattle infected with T. congolense. The following details are likely to be of interest for their theoretical bearling and also because more than two million doses of one of these drugs, 2 : 7-diamino-9-phenyl-10-methylphenanthridinium bromide (No. 1553 or 'dimidium bromide', see formula), have been administered to cattle in Africa, and very considerable outbreaks of trypanosomiasis have,been controlled by its use (The Times, February 9).

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BROWNING, C. Chemotherapy of T. congolense Infections with Phenanthridine Compounds : Biological Aspects. Nature 163, 590–591 (1949). https://doi.org/10.1038/163590a0

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