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Androgen-modified expression compared with Y linkage of male specific antigen

Abstract

SEVERAL recent results have led to a widely held view that the male specific antigen (MSA) is coded for by a structural gene on the Y chromosome, and because of this it is frequently termed H-Y (refs 1 and 2). Although a good case has been put forward for this conclusion, there are some data that conflict with this view and some arguments against the notion. These are presented here as a reminder that, as is so often the case with biological experiments, the Scottish verdict “not proven” holds.

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References

  1. Nature, 232, 441 (1971).

  2. Gerald, P. S., New Engl. J. Med., 293, 1095 (1975).

    Article  CAS  Google Scholar 

  3. Ohno, S., Cell, 7, 315–321 (1976).

    Article  CAS  Google Scholar 

  4. Ohno, S., New Engl. J. Med., 295, 1011–1012 (1976).

    Article  CAS  Google Scholar 

  5. Ohno, S., Christian, L. C., Wachtel, S. S., and Koo, G. C., Nature, 261, 597–599 (1976).

    Article  ADS  CAS  Google Scholar 

  6. Watchel, S. S., Ohno, S., Koo, G. C., and Boyse, E. A., Nature, 257, 235–236 (1975).

    Article  ADS  Google Scholar 

  7. Cattanach, B. M., Pollard, C. E., and Hawkes, S. G., Cytogenetics, 10, 318–337 (1971).

    Article  CAS  Google Scholar 

  8. Cattanach, B. M., in The Early Development of Mammals (edit. by Balls, M., and Wild, A. E.), 305–317 (Cambridge University Press, 1975).

    Google Scholar 

  9. Bennett, D., et al., Nature, 257, 236–238 (1975).

    Article  ADS  CAS  Google Scholar 

  10. Attardi, B., and Ohno, S., Cell, 2, 205–212 (1974).

    Article  CAS  Google Scholar 

  11. Gehring, U., and Tomkins, G. M., Cell, 3, 59–64 (1974).

    Article  CAS  Google Scholar 

  12. Keenan, B. S., Meyer, W. J., III Hadjian, A. J., Jones, H. W., and Migeon, C. J., J. clin. Endocr. Metab., 38, 1143–1146 (1974).

    Article  CAS  Google Scholar 

  13. Goldberg, E. H., Boyse, E. A., Bennett, D., Scheid, M., and Carswell, E. A., Nature, 232, 478–480 (1971).

    Article  ADS  CAS  Google Scholar 

  14. Wachetel, S. S., et al., Proc. natn. Acad. Sci. U.S.A., 71, 1215–1218 (1974).

    Article  ADS  Google Scholar 

  15. Wachetel, S. S., Koo, G. C., and Boyse, E. A., Nature, 254, 270–272 (1975).

    Article  ADS  Google Scholar 

  16. Oliver, R. T. D., Eur. J. Immun., 4, 519–520 (1974).

    Article  CAS  Google Scholar 

  17. Festenstein, H., Sachs, J. A., Paris, A. M. I., Pegrum, G. D., and Moorhead, J. F., Lancet, i, 157–161 (1976).

    Article  Google Scholar 

  18. Erickson, R. P., Transplant. Bull., 30, 25–28 (1962).

    Article  CAS  Google Scholar 

  19. Cooke, H., Nature, 262, 182–186 (1976).

    Article  ADS  CAS  Google Scholar 

  20. Bunker, M. C., Can J. Genet. Cytol., 8, 312–327 (1966).

    Article  CAS  Google Scholar 

  21. Eichwald, E. J., Davidson, N., Folia Biol., 14, 89–93 (1968).

    CAS  Google Scholar 

  22. Hildemann, W. H., and Cooper, E. L., Transplantation, 5, 707–720 (1967).

    Article  CAS  Google Scholar 

  23. Hildemann, W. H., Morgan, M., and Frautnick, L., Transplant. Proc., 24–31 (1970).

  24. Uphoff, D. E., Transplantation, 20, 78–81 (1975).

    Article  CAS  Google Scholar 

  25. Gasser, D. L., Silvers, W. K., and Wachtel, S. S., Science, 185, 963 (1974).

    Google Scholar 

  26. Baseknik, M. I., and Demin, Y. S., Genetika, U.S.S.R., 11, 62–67 (1975).

    Google Scholar 

  27. Wachtel, S. S., et al., New Engl. J., Med., 293, 1060–1072 (1975).

    Article  Google Scholar 

  28. Wachtel, S. S., et al., New Engl. J., Med., 295, 750–754 (1976).

    Article  CAS  Google Scholar 

  29. Soller, M., Padeh, B., Wysoki, M., and Ayalon, N., Cytogenetics, 8, 51–67 (1969).

    Article  CAS  Google Scholar 

  30. Fredga, K., Gropp, A. C., Winking H., and Frank, F., Nature, 261, 225–227 (1976).

    Article  ADS  CAS  Google Scholar 

  31. Vojtiskova, M., and Polackova, M., Folia Biol., 12, 137–140 (1966).

    CAS  Google Scholar 

  32. Polackova, M., and Vojtiskova, M., Folia Biol., 14, 93–100 (1968).

    CAS  Google Scholar 

  33. Silvers, W. K., Billingham, R. E., and Sanford, B. M., Nature, 220, 401–403 (1968).

    Article  ADS  CAS  Google Scholar 

  34. Vojtiskova, M., and Polackova, M., Folia Biol., 18, 209–212 (1972).

    CAS  Google Scholar 

  35. Vojtiskova, M., and Polackova, M., Folia Biol., 19, 381–384 (1973).

    CAS  Google Scholar 

  36. Hirota, Y., Suzuki, T., Chazono, Y., and Bito, Y., Immunology, 30, 341–348 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Wachtel, S. S., Gasser, D. L., and Silvers, W. K., Science, 181, 862–863 (1973).

    Article  ADS  CAS  Google Scholar 

  38. Hampl, P. H., Ivanyi, P., and Starka, L., Steroidologia, 2, 113 (1971).

    CAS  PubMed  Google Scholar 

  39. Ivanyi, P., Hampl, R., Starka, L., and Mickova, M., Nature new Biol., 238, 280 (1972).

    Article  CAS  Google Scholar 

  40. Gordon, R. D., Simpson, E., and Samelson, L. E., J. exp. Med., 142, 1108–1120 (1975).

    Article  CAS  Google Scholar 

  41. Zinkernagel, R. M., and Doherty, P. C., Nature, 248, 701–702 (1974).

    Article  ADS  CAS  Google Scholar 

  42. Shearer, G. M., Eur. J. Immun., 4, 527 (1974).

    Article  CAS  Google Scholar 

  43. Schrader, J. W., Cunningham, B. A., and Edelman, G. M., Proc. natn. Acad. Sci. U.S.A., 72, 5066–5070 (1975).

    Article  ADS  CAS  Google Scholar 

  44. Polackova, M., Viklicky, V., and Vojtiskova, M., Folia Biol., 21, 20–26 (1975).

    CAS  Google Scholar 

  45. Beatty, R. A., Indian J. Hered., 1, 9–21 (1969).

    Google Scholar 

  46. Brozek, X., Acta Biol. Cracoviensia, 13, 189–198 (1970).

    Google Scholar 

  47. Krzanowska, H., Acta Biol. Cracoviensia, 9, 61–70 (1966).

    Google Scholar 

  48. Krzanowska, H., Genet. Res., 13, 17–24 (1969).

    Article  CAS  Google Scholar 

  49. Weir, J., and Hogle, G., Genetics, 73, 17–24 (1969).

    Google Scholar 

  50. Selmanoff, M. K., Jumonville, J. E., Maxson, S. C., and Ginsberg, B. E., Nature, 253, 529–530 (1975).

    Article  ADS  CAS  Google Scholar 

  51. Shire, J. G. M., Nature, 250, 499–500 (1974).

    Article  Google Scholar 

  52. Palmiter, R. D., Biochemistry, 10, 4399–4403 (1971).

    Article  CAS  Google Scholar 

  53. Sunshine, G. H., Williams, D. J., and Rabin, B. R., Nature new Biol., 230, 133–136 (1971).

    Article  ADS  CAS  Google Scholar 

  54. Blyth, C. A., Freedman, R. B., and Rabin, B. R., Nature new Biol., 230, 137–139 (1971).

    Article  CAS  Google Scholar 

  55. Gustafson, J.-A., Ingelman-Sundberg, M., and Steinberg, A., J. Steroid Biochem., 6, 643–649 (1975).

    Article  Google Scholar 

  56. Szego, C. M., Davis, J. S., Proc. natn. Acad. Sci. U.S.A., 58, 1711–1718 (1967).

    Article  ADS  CAS  Google Scholar 

  57. Friedman, N., Exton, J. H., and Park, C. R., Biochem. biophys. Res. Commun. 129, 113–119 (1967).

    Article  Google Scholar 

  58. Mendelsohn, J. S., Multer, M. M., and Boone, R. F., J. clin. Invest., 53, 2129–2137 (1973).

    Article  Google Scholar 

  59. Szego, C. M., Fedn Proc., 24, 1343–1352 (1965).

    CAS  Google Scholar 

  60. Smith, L. D., and Ecker, R. E., Devl. Biol., 25, 232–247 (1971).

    Article  CAS  Google Scholar 

  61. Gasser, D. L., and Silvers, W. K., Adv. Immun., 15, 215–248 (1972).

    Article  CAS  Google Scholar 

  62. Krco, C. J., and Goldberg, E. H., Science, 193, 1134–1135 (1976).

    Article  ADS  CAS  Google Scholar 

Download references

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ERICKSON, R. Androgen-modified expression compared with Y linkage of male specific antigen. Nature 265, 59–61 (1977). https://doi.org/10.1038/265059a0

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