Abstract
OXIDATION of pyruvate in perfused rat heart is inhibited by diabetes and by oxidation of fatty acids and ketone bodies1. Enhanced release and oxidation of fatty acids from muscle glycerides may be an important factor in the effects of diabetes2–4. These effects on pyruvate oxidation have generally been attributed to inhibition of pyruvate dehydrogenase, and regulation of this enzyme is considered to be of crucial importance in the selection of fuels for respiration and in the metabolic changes in heart and other tissues in diabetes and starvation.
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COOPER, R., RANDLE, P. & DENTON, R. Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction. Nature 257, 808–809 (1975). https://doi.org/10.1038/257808a0
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DOI: https://doi.org/10.1038/257808a0
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