Abstract
BARBITURATES are commonly used to prevent epileptic seizures1, but it has also been observed that susceptibility to ‘spontaneous’ seizure in both normal humans and animals is increased during abrupt withdrawal from chronically administered barbiturates and other central nervous system depressants2. Here we show that barbiturate withdrawal is highly effective in producing audiogenic seizure susceptibility in a strain of mice which are normally resistant to seizure.
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References
Browning, R. A., and Maynert, E. W., in Antiepileptic Drugs (edit. by Woodbury, T. M., Penry, J. K., and Schmidt, R. P.), 345 (Raven, New York, 1972).
Wikler, A., and Essig, C. F., Epilepsy mod. Probl. Pharmacopsychiat., 4, 170 (1970).
Huff, S. D., and Fuller, J. L., Science, 144, 304 (1964).
Fuller, J. L., and Collins, R. L., Devl. Psychobiol., 1, 185 (1968).
Iurrian, W. C., and Fink, G. B., Devl. Psychobiol., 1, 230 (1968).
Saunders, J. C., Bock, G. R., Chen, C.-S., and Gates, G. R., Expl Neurol., 36, 426 (1972).
Gates, G. R., Chen, C.-S., and Bock, G. R., Expl Neurol., 38, 488 (1973).
Chen, C.-S., Gates, G. R., and Bock, G. R., Expl Neurol., 39, 277 (1973).
McGinn, M. D., Willott, J. F., and Henry, K. R., Nature new Biol., 244, 255 (1973).
Willott, J. F., and Henry, K. R., J. comp. physiol. Psychol., 86, 1 (1974).
Sharpless, S. K., in Basic Mechanisms of the Epilepsies (edit. by Jasper, H. H., Ward, A. A., and Pope, A.), 329 (Little, Brown, Boston, 1969).
Bock, G. R., PhD Thesis, (Monash University, Australia 1973).
Jaffe, J. H., and Sharpless, S. K., Res. Publs Ass. Res. nerv. ment. Dis., 47, 226 (1967).
Gates, G. R., and Chen, C. S., Expl Neurol., 41, 457 (1973).
Fuller, J. L., and Wimer, R. E., in Biology of the Laboratory Mouse (edit. by Green, E. L.), 609 (McGraw-Hill, New York, 1966).
Freund, G., and Walker, D. W., Psychopharmacologia Berlin, 22, 45 (1971).
Saunders, J. C., Bock, G. R., James, R., and Chen, C.-S., Expl Neurol., 37, 388 (1972).
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GATES, G., CHEN, CS. Effects of barbiturate withdrawal on audiogenic seizure susceptibility in BALB/c mice. Nature 249, 162–164 (1974). https://doi.org/10.1038/249162a0
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DOI: https://doi.org/10.1038/249162a0
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