Abstract
THE allowed conformations of nucleic acids depend on the flexibility of the structure of the nucleotides from which they are constructed. Many X-ray crystallographic studies of the degree of flexibility of these structures have shown that nucleosides exhibit a larger number of preferred conformations than nucleotides, and this led Sundaralingam1 to suggest that a nucleotide is more ‘rigid’ than a nucleoside. Berthod and Pullman2, however, have drawn attention to the fact that considerations of conformational energy do not imply such a rigid structure.
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References
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YOUNG, D., TOLLIN, P. & WILSON, H. Molecular conformation of deoxyguanosine 5′-phosphate. Nature 248, 513–514 (1974). https://doi.org/10.1038/248513a0
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DOI: https://doi.org/10.1038/248513a0
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