Abstract
An increase in chromosome number accompanies reversion of subtetraploid mouse cell lines from malignant transformed phenotype to growth-controlled normal phenotype. When growth control is once again lost, the chromosome number drops back to the subtetraploid mode.
Similar content being viewed by others
Article PDF
References
Harris, M., Cell Culture and Somatic Variation (Holt, Rinehart and Winston, New York, 1964).
Swim, H., Ann. Rev. Microbiol., 13, 141 (1959).
Aaronson, S., and Todaro, G., Science, 162, 1024 (1968).
Todaro, G., and Green, H., J. Cell Biol., 17, 299 (1963).
Gey, G., Cancer Research, 1, 737 (1941).
Holley, R., and Kiernan, J., Proc. US Nat. Acad. Sci., 60, 300 (1968).
Dulbecco, R., and Stoker, M., Proc. US Nat. Acad. Sci., 66, 204 (1970).
Pollack, R., and Teebor, G., Cancer Res., 29, 1770 (1969).
Sanford, K., Intern. Rev. Cytol., 18, 249 (1965).
Jarrett, O., and Macpherson, I., Intern. J. Cancer, 3, 654 (1968).
Defendi, V., and Lehman, J., J. Cell. Comp. Physiol., 66, 351 (1965).
Todaro, G., Nilausen, K., and Green, H., Cancer Res., 23, 825 (1963).
Pollack, R., Green, H., and Todaro, G., Proc. US Nat. Acad. Sci., 60, 126 (1968).
Rabinowitz, Z., and Sachs, L., Nature, 220, 1203 (1963).
Marin, G., and Littlefleld, J., J. Virol., 2 69 (1968).
Sambrook, J., Westphal, H., Srinivasan, R., and Dulbecco, R., Proc. US Nat. Acad. Sci., 60, 1288 (1968).
Westphal, H., and Dulbecco, R., Proc. US Nat. Acad. Sci., 59, 1158 (1968).
Benjamin, T., J. Mol. Biol., 16, 359 (1966).
Benjamin, T., and Burger, M., Proc. US Nat. Acad. Sci. (in the press).
Benjamin, T., Proc. US Nat. Acad. Sci. (in the press).
Eckhart, W., Dulbecco, R., and Burger, M., Proc. US Nat. Acad. Sci. (in the press).
Marin, G., and Macpherson, I., J. Virol., 3, 146 (1969).
Weiss, M., Ephrussi, B., and Scalletta, L., Proc. US Nat. Acad. Sci., 59 1132 (1968).
Pollack, R., and Burger, M., Proc. US Nat. Acad. Sci., 62, 1074 (1969).
Inbar, M., Rabinowitz, Z., and Sachs, L., J. Cancer, 4, 690–696 (1969).
Rabinowitz, Z., and Sachs, L., Virology, 38, 336 (1969).
Hsu, T., and Benirschke, K., An Atlas of Mammalian Chromosomes (Springer-Verlag, New York, 1968).
Hsu, T., and Klatt, O., J. Nat. Cancer Inst., 21, 437 (1958).
Hsu, T., Intern. Rev. Cytology, 12, 69 (1961).
Vogt, H., Genetics, 44, 1257 (1959).
Todaro, G., Green, H., and Goldberg, B., Proc. US Nat. Acad. Sci., 51, 66 (1964).
Koprowski, H., Ponten, J., Jensen, F., Ravdin, R., Moorhead, P., and Saksela, E. J., J. Cell. Comp. Physiol., 59, 281 (1962).
Eagle, H., and Piez, K., J. Exp. Med., 116, 29 (1962).
Rabinowitz, Z., and Sachs, L., Nature, 225, 136 (1970).
Levan, A., Exp. Cell Res., 11, 613 (1956).
Aub, J., Sanford, B., and Wang, L., Proc. US Nat. Acad. Sci., 54, 400 (1965).
Burger, M., Nature, 219, 499 (1968).
Burger, M., Proc. US Nat. Acad. Sci., 62, 994 (1969).
Burger, M., and Goldberg, A., Proc. US Nat. Acad. Sci., 57, 359 (1967).
Inbar, M., and Sachs, L., Nature, 223, 710 (1969).
Inbar, M., and Sachs, L., Proc. US Nat. Acad. Sci., 63, 1418 (1969).
Häyry, P., and Defendi, V., Virology, 41, 22 (1970).
Burger, M., Nature, 227, 170 (1970).
Lewis, E., Adv. Genetics, 3, 73 (1950).
Demerec, M., and Slizynska, H., Genetics, 22, 641 (1937).
Seiss, M., Todaro, G., and Green, H., J. Cell Physiol., 71, 105 (1968).
Weiss, M., Proc. US Nat. Acad. Sci., 66, 79 (1970).
Warris, H., Miller, O., Klein, G., Worst, P., and Tachibana, T., Nature, 223, 363 (1969).
Silagi, S., and Bruce, S., Proc. US Nat. Acad. Sci., 66, 72 (1970).
Todaro, G., and Green, H., Virology, 24, 393 (1964).
Hsu, T., and Somers, C., Exp. Cell Res., 26, 404 (1962).
Methods in Cancer Research (edit. by Busch, H.) 3, chap. 9, 10 (Academic Press, New York, 1967).
Mauer, A., Saunders, E., and Lampkin, B., Rec. Res. Cancer Res., 17, 168 (1969).
Clarkson, B., Fried, J., and Ogawa, M., Rec. Res. Cancer Res., 17, 175 (1969).
Kiefer, B., Entelio, C., and Infante, A., Proc. US Nat. Acad. Sci., 64, 857(1969).
Puck, T., and Marcus, P., J. Exp. Med., 103, 653 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
POLLACK, R., WOLMAN, S. & VOGEL, A. Reversion of Virus-transformed Cell Lines: Hyperploidy accompanies Retention of Viral Genes. Nature 228, 938 (1970). https://doi.org/10.1038/228938a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/228938a0
This article is cited by
-
Inducing stable reversion to achieve cancer control
Nature Reviews Cancer (2016)
-
Characterization of a stable, anchorage-dependent clone obtained from a spontaneously transformed mouse cell line
In Vitro (1984)
-
Characterization of cell lines derived from hamster tumors induced with the BK virus
Archives of Virology (1976)
-
General Polyploid produced by Cytochalasin B
Nature New Biology (1973)
-
Tumorous cultures of Crepis capillaris: chromosomes and growth
Chromosoma (1973)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.