Abstract
CERTAIN strains of Friend leukaemia virus induce hyper-volemic polycythaemia1 and macroscopic foci of proliferating haemopoietic cells2 in the spleens of susceptible mice. Among several strains of Friend virus studied, the viral component which initiates spleen focus formation (SFFV) and that which induces polycythaemia (FV-P) were found to be closely associated; thus both host responses are considered to be elicited by the same virus3. The erythropoiesis induced by this virus is independent of erythropoietin because this substance could not be detected in plasma or urine of mice at any time after infection, and administration of rabbit anti-erythro-poietin serum did not alter susceptibility to SFFV (ref 4). Resumption of erythropoiesis and formation of spleen foci can be induced by this virus in plethorized mice3,5, and so the virus presumably interacts with very primitive haemopoietic cells, perhaps colony-forming or erythro-poietin-sensitive cells.
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STEEVES, R., BENNETT, M., MIRAND, E. et al. Genetic Control by the W Locus of Susceptibility to (Friend) Spleen Focus-forming Virus. Nature 218, 372–374 (1968). https://doi.org/10.1038/218372a0
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DOI: https://doi.org/10.1038/218372a0
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