Abstract
INACTIVATION by acetylation of the anti-tuberculosis drug isoniazid in vivo is subject to genetic polymorphism1–3. Studies of the gene frequency for rapid inactivation in different regions have revealed considerable racial variations4–7. Because of the association of isoniazid neuropathy with slow inactivation of the drug in therapeutic practice8,9, the recording of gene frequencies among different races and in different countries is of practical importance. It is also of ethnological value in studies of population migrations. This communication reports such an investigation among Burmese subjects.
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SMITH, S., KYI, T. Inactivation of Isoniazid in Burmese Subjects. Nature 217, 1273 (1968). https://doi.org/10.1038/2171273a0
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DOI: https://doi.org/10.1038/2171273a0
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