Abstract
PROSTAGLANDINS have a wide distribution in the vertebrate body and have been shown to be pharmacologically active on many types of vertebrate tissues. Evidence that these compounds have a neurohumoral role is suggested by several findings. Prostaglandins are widely distributed in the central nervous system1, and in the rat cerebral cortex they are localized in synaptic vesicles2. They are released from the feline cortex3 and possibly cerebellum and ventricles4,5. In addition, prostaglandins have effects on the central nervous system of cats and chickens6,7. We decided to investigate the effects of prostaglandins on the isolated toad spinal cord because the preparation is convenient for studying direct actions of drugs on a neuronal pool. Furthermore, prostaglandins are released from the frog spinal cord on stimulation of the hind limbs8, suggesting that they are involved in synaptic transmission in amphibians.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Horton, E. W., and Main, I. H. M., Brit. J. Pharmacol. Chemother., 30, 582 (1967).
Kataoka, K., Ramwell, P. W., and Jessup, S., Science, 157, 1187 (1967).
Ramwell, P. W., and Shaw, J. E., Amer. J. Physiol., 211, 125 (1966).
Coceani, F., and Wolfe, L. S., Canad. J. Physiol. Pharmacol., 43, 445 (1965).
Feldberg, W., and Myers, R. D., J. Physiol., 184, 837 (1966).
Avanzino, G. L., Bradley, P. B., and Wolstencroft, J. H., Brit. J. Pharmacol. Chemother., 27, 157 (1966).
Horton, E. W., and Main, I. H. M., Brit. J. Pharmacol. Chemother., 30, 568 (1967).
Ramwell, P. W., Shaw, J. E., and Jessup, R., Amer. J. Physiol., 211, 998 (1966).
Phillis, J. W., and Tebēcis, A. K., Comp. Biochem. Physiol., 23, 541 (1967).
Tebēcis, A. K., and Phillis, J. W., Comp. Biochem. Physiol., 23, 553 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PHILLIS, J., TEBĒCIS, A. Prostaglandins and Toad Spinal Cord Responses. Nature 217, 1076–1077 (1968). https://doi.org/10.1038/2171076a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2171076a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
