Abstract
A NUMBER of investigators1–5 have induced infertility in female animals by repeatedly injecting sperm, with or without adjuvants. Although these authors have sought to determine the factors responsible for the reduction in fertility, the specific mechanism has not yet been identified. The possibility that the effect might be produced by pathological changes was ruled out by Isojima et al.1 on the basis of their histological examinations. In our study of the processes involved, however, we found that animals injected with sperm and adjuvant developed amyloidosis. This illness, not previously reported in guinea-pigs as a consequence of immunization, may explain the low fertility.
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References
Isojima, S., Graham, R., and Graham, J., Science, 129, 44 (1959).
Katsh, S., Amer. J. Obst. and Gynec., 78, 276 (1959).
Otani, Y., Behrman, S. J., Porter, C. W., Nakayama, M., Intern. J. Fertil., 8, 835 (1963).
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Cohen, A. S., Intern. Rev. Exp. Pathol. (edit. by Richter, G. W., and Epstein, M. A.), 4 (1965).
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PLANK, S., HUNT, R. & COHEN, A. Amyloidosis in Guinea-pigs immunized with Sperm and Adjuvant. Nature 214, 1368–1369 (1967). https://doi.org/10.1038/2141368a0
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DOI: https://doi.org/10.1038/2141368a0
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