Abstract
BUFFERED solutions of certain aromatic acids dissolve human plasma clots when incubated with them in vitro1,2. The most active in this respect have proved to be arylcarboxylates, which possess an additional free rotating phenyl ring, for example, N-phenylanthranilates3, 5-benzyloxysalicylates4 and diphenylethylacetate5. It was suggested that non-condensed aryl rings in the presence of an acidic functional group are required to render a highly active fibrinolytic agent5.
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von Kaulla, K. N., Arzneimittel Forsch., 15, 246 (1965).
von Kaulla, K. N., Thromb. Diath. Haem., 7, 404 (1962).
Gryglewski, R. J., and Gryglewska, T., Biochem. Pharmacol., 15, 1171 (1966).
von Kaulla, K. N., Experientia, 21, 439 (1965).
Gryglewski, R. J., Folia Biol., 14, 3 (1966).
von Kaulla, K. N., J. Med. Chem., 8, 164 (1965).
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GRYGLEWSKI, R., ECKSTEIN, M. Fibrinolytic Activity of some Biarylcarboxylic Acids. Nature 214, 626 (1967). https://doi.org/10.1038/214626a0
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DOI: https://doi.org/10.1038/214626a0
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