Abstract
IT has been claimed that eugenol, 4-oxy-3-methoxy-1-allylbenzoic acid, has mucinogenic activity and that it has a beneficial effect on gastric ulcers1,2. The gastric wall contains various uronic acid containing mucopoly-saccharides, the formation of which is possibly dependent on a proper coupling capacity of β-D-glucosiduronic acid (UDPGA). Evidence has been obtained which indicates that the amount and type of mucopolysaccharides in tissues probably have some bearing on the mechanism of ulcer formation3. This investigation was undertaken in order to determine whether eugenol has any effect on the glucuronation of an exogenic substance. The effect on the whole conjugation capacity of the tissue, as well as on the UDPGA transferase enzyme, was also considered in the investigation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hollander, F., and Lauber, F. U., Proc. Soc. Exp. Biol. and Med., 67, 34 (1948).
Sober, H. A., Hollander, F., and Sonnenblick, B. P., Amer. J. Physiol., 162, 120 (1950).
Hartiala, K., and Häkkinen, I., Acta Physiol. Scand. (in the press).
Häkkinen, I., Hartiala, K., and Lang, H., Acta Physiol. Scand. (in the press).
Levvy, G. A., and Storey, D. E., Biochem. J., 64, 295 (1949).
Hartiala, K. J. W., and Rontu, S., Ann. Med. Exp. Fenn., 33, 213 (1955).
Bogell, B. M., and Leloir, L. E., J. Biol. Chem., 236, 293 (1961).
Raussi, M., and Hartiala, K., Acta Physiol. Scand., 59, Suppl. 213, 125 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HARTIALA, K., PULKKINEN, M. & BALL, P. Inhibition of β-D-Glucosiduronic Acid Conjugation by Eugenol. Nature 210, 739–740 (1966). https://doi.org/10.1038/210739a0
Issue Date:
DOI: https://doi.org/10.1038/210739a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
