Abstract
SUBSTANCES which have been introduced into the body by intravenous injection are eliminated from the blood in accordance with a mathematically definable pattern1. The results of heterozygote tests in phenylketonuria after oral administration of phenylalanine2,3, however, do not make directly possible any estimation of the elimination rate from the blood. It is possible that, according to the configuration of the tolerance curves, the elimination of phenylalanine from the blood occurs at the same speed in controls as in heterozygous carriers4. It would be difficult to explain this mode if the velocity of elimination were primarily a function of the activity of phenylalanine hydroxylase4.
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BREMER, H., NEUMANN, W. Tolerance of Phenylalanine after Intravenous Administration in Phenylketonurics, Heterozygous Carriers, and Normal Adults. Nature 209, 1148–1149 (1966). https://doi.org/10.1038/2091148a0
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DOI: https://doi.org/10.1038/2091148a0
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